01 69 36 11 15

R&D et collaborative
    projects

1 er
  LABORATOIRE
  INDEPENDANT
  en Europe
 100%
dédié à l'identification des
Perturbateurs Endocriniens

PrecisionTox


The goal of PrecisionTox is to better protect the health of people and the environment by providing faster and more accurate methods to accelerate chemical safety testing by bringing toxicology to a new era, without the need for laboratory animal testing. Laboratoire WatchFrog are currently developing and employing a medium throughput assay with Xenopus embryos. This assay will provide essential toxicological information at a transcriptomic and metabolomic level of the effects of 250 reference chemicals in a vertebrate organism.
Partners :
THE UNIVERSITY OF BIRMINGHAM, ALTERTOX, MISVIK BIOLOGY, CELL NETWORKS GMBH, HEIDELBERG UNIVERSITY (DE), HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH, KARLSRUHER INSTITUTE FOR TECHNOLOGY, LATVIA MGI TECH SIA, CRG CENTRE FOR GENOMIC REGULATION, LEITAT, MICHABO HEALTH SCIENCE LTD, OXFORD UNIVERSITY, CLEMSON UNIVERSITY (US), INDIANA UNIVERSTY (US).

Financing :
European Union’s Horizon 2020

ATHENA


European Consortium aims to mobilise the scientific progress made in recent years to develop and validate new OECD methods for thyroid hormone axis disrupting-chemicals. Watchfrog Laboratory will develop the automation of its XETA test, TG OECD 248.

Partners:
Brunel University London, Denmarks Tekniske University, Charite University Berlin, CNRS, Stiching VU, Karolinska Institute, Karlstads University, Erasmus University center Rotterdam.

Financing:
European Union’s Horizon 2020

THYROGENOX


Screening of the activity of plant protection products on thyroid hormones signaling.
Amphibian models are combined with toxicogenomics approaches to study possible impacts on neurodevelopment.



Partners:
Laboratoire Watchfrog, ENS of Lyon

Financing:
ANSES

SVEH (Hospital Water Monitoring)


The aim of SVEH was to create a mobile platform to monitor industrial waste water, in particular in the context of hospital and healthcare institutions. A laboratory van has been built integrating bioassays and innovative chemical analytical tools. It is available for measuring the environmental impact of chemical pollution of water.

Partners:
Laboratoire Watchfrog, TOXEM, PROFILOMIC, ALYXAN, Centre Hospitalier Sud Francilien d’Evry, PIREN SEINE, UNIV BORDEAUX 1 UMR CNRS EPOC, UNIV PARIS-SUD EQUIPE SPE UMR 8079, NOVA GREEN

Financing:
AP ECO INDUSTRIE (Ministry of Industry)

SOLUTIONS


European consortium to achieve the development of methods and strategies to help the authorities defining new water and environmental regulation to address chemical pollution. This consortium has published many guidance documents describing methodologies and suggesting how and when to apply these approaches.



Partners :
UFZ, Deltares, EI, IVL, JRC, KWR, Eawag, NIVA, LMC, OEKO, SU, RIVM, Alterra, CSIC, FB, Brunel, VITO, UNOL, Watchfrog, UNSPMF, MAXX, INERIS, UU, SYNCHEM, UOB, ULIV, ICPDR, DYNEX, NJU, RWTH, MU, Mermayde, IPB, HAM, UGOT, KOCMOC, UB, UQ, UNICAMP, Universidade Estadual de Campinas

Financing :
UE FP7

TOXSYN


Development of tools to study combination and low dose effects of endocrine active substances.
Focus on endocrine mechanisms related to the nuclear receptors PPAR and PXR known to be involved in physiological responses to drugs.

Partners:
Laboratoire Watchfrog, CNRS, ENS of Lyon, Inserm, University of Montpellier

Financing:
ANR


AMBRe (Alternative Models for Brain Research)


The aim of AMBRe was to develop amphibian models of neurodegenerative lesions to contribute towards screening of therapeutic drugs. The results of the project have led to the establishment of a service for the screening of drug candidates for neurodegenerative diseases.



Partners :
Laboratoire Watchfrog, CNRS, INSERM, Museum of Natural History, University of Orsay

Financing :
FUI (Ministry of Industry, IDF Region, Essonne Department)

THYPEST


Testing of the activity of two plant protection products on thyroid hormones signaling.
Amphibian models are combined with behavioral observations, histology, and gene expression approaches.

Partners:
Laboratoire Watchfrog, CNRS / Museum of Natural History

Financing:
ANSES




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